Home Subscription Services
 
   

 
The Journal of Adhesive Dentistry
EJED Home Page
About the Editor
Editorial Board
Submit
Author Guidelines
Submission Form
Reprints / Articles
Permissions
Advertising
MEDLINE Search
Official Site
 
 
 
 
 
FacebookTwitter
Quintessence Publishing: Journals: EJOI

 

European Journal of Oral Implantology

Editor in Chief: Dr. Marco Esposito

Official publication of the British Society of Oral Implantology (BSOI) and the Dutch Society of Oral Implantology (NVOI)

ISSN (print) 1756-2406 • ISSN (online) 1756-2414

Publication:

Summer 2010
Volume 3 , Issue 2

Back
Share Abstract:

Markers of systemic inflammation in periodontal patients: chronic versus aggressive periodontitis. An explorative cross-sectional study

Cairo, Francesco / Nieri, Michele / Gori, Anna Maria / Tonelli, Paolo / Branchi, Roberto / Castellani, Sergio / Abbate, Rosanna / Pini-Prato, Giovan Paolo

Aim: The aim of this study was to evaluate differences in the inflammatory profile of young (≤40 years) systemically healthy periodontal patients comparing chronic (CP) versus aggressive periodontitis (AP) in terms of cytokines, chemokines and C-reactive protein levels. Methods: Systemically healthy subjects affected by severe CP or AP were enrolled in this study. Differential diagnosis was performed according to the criteria suggested by the American Academy of Periodontology. Blood samples for the evaluation of high sensitivity C-reactive protein levels, cytokine levels (IL-1β, IL-1RA, IL-4, IL-6, IL-10, IL-12, interferon-γ, interferon-γ-inducible protein 10, tumour necrosis factor α) and chemokine levels (IL-8, vascular endothelial growth factor, monocyte chemoattractant protein 1, macrophage inflammatory protein 1α and macrophage inflammatory protein 1β) were obtained from all patients. Results: A total of 45 systemically healthy patients with severe periodontitis were consecutively selected, 21 with CP (mean age 36.8 3.5; mean clinical attachment level [CAL] 4.72 0.69) and 24 with AP (mean age 35.9 3.8; mean CAL 4.68 0.75). No statistically significant difference between the two groups was detected for periodontal variables and for all the investigated inflammatory markers. Conclusions: The inflammatory profile of severe periodontitis in young patients (≤40 years) may be similar for chronic and aggressive types. Differential diagnosis between CP and AP may not be able to detect a different systemic inflammatory profile in young adults.

Keywords: aggressive periodontitis, chemokines, chronic periodontitis, cytokines, host response, systemic inflammation

Full Text PDF File | Order Article

 

 
  © 2014 Quintessence Publishing Co Inc
 

Home | Subscription Services | Books | Journals | Multimedia | Events | Blog
Terms of Use | Privacy Policy | About Us | Contact Us | Advertising | Help | Sitemap | Catalog