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Quintessence Publishing: Journals: CMF

 

Journal of Craniomandibular Function

Editor in Chief: Prof. Dr. Wolfgang B. Freesmeyer, Berlin

Official publication of the International Society of Computerized Dentistry

ISSN 1868-4149

Publication:

Summer 2009
Volume 1 , Issue 2

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Cell biological basics of a motion-based therapy in arthritis - an overview

Deschner, James / Rath-Deschner, Birgit / Reimann, Susanne / Bourauel, Christoph / Agarwal, Sudha / Jepsen, Søren / Jäger, Andreas



Pages: 107 - 123

Background: Arthritis is an inflammatory disorder that is often associated with the loss of structure and function of the joints such as the temporomandibular joint. Motion-based therapies and mechanical loading of joints are a promising therapeutic approach in arthritis. Objective: This review is dedicated to the question how the clinically positive effects of mechanical joint loading and motion-based therapy, respectively, are accomplished at cellular and molecular levels. Summary: In various studies it has been shown that synthesis of proinflammatory mediators, matrix-degrading enzymes, and mediators of bone resorption can be inhibited by applying dynamic tensile strain to articular cells. These joint-protective effects are dependent on duration, amplitude, and frequency of strain. However, static tensile strain applied to joint cells seems to inhibit the synthesis of reparative molecules. Conclusion: Numerous in-vitro, animal, and clinical studies emphasize the great potential that a controlled clinical application of biomechanical loading may have for prevention and therapy of inflammatory temporomandibular joint disorders.

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