Objective: To evaluate the value of the invasive front grading (IFG), the PCNA, the ki67, and the p53 content at the invasive tumor front (ITF) of oral squamous cell carcinoma. Methods: All 62 tumors were graded using IFG grading. The content of PCNA, ki67, and p53 were evaluated at the ITF. Results: The PCNA LI (p<0.01), the ki67 LI (p<0.05), and the p53 LI (p<0.01) at the ITF were significantly associated with the IFG score. The cumulative survival rate for high-IFG-score (>9) patients was significantly better than that for low-IFG-score (50%) was significantly correlated with poor survival rates (p<0.05). The complete IFG score was a significant factor in both univariate and multivariate Cox’s analysis (p<0.01 p<0.05), and the TNM staging and PCNA LI was only a significant factor in univariate Cox’s analysis (p<0.01, p<0.05). Both ki67 LI and p53 LI were nonsignificant factors in predicting the survival of OSCC patients (p>0.05). Conclusion: The results of this study confirm the potential prognostic value of IFG system for patients with OSCC.