Objective: To investigate the clinical pathological features of mucinous adenocarcinoma of salivary glands. Methods: The clinical manifestation and histopathological characteristics of six cases of mucinous adenocarcinoma of salivary glad were studied by retrospective and routine histopathology and immunohistochemistry. Results: Mucinous adenocarcinoma occurred in the palate (4 cases) and in the mouth floor (2 cases). Average age of patients was 60 years (range 48 to 70 years) and males were affected more often than females (ratio 4:2). Pathologically, the tumor grew with infiltration of surrounding tissues. The tumor consisted of unitary mucinous cells, cell pleomorphism and nuclear mitosis was often present. Some tumors showed acinus-like structure. Tumor cells often formed incomplete duct-like structure and small clusters floating in a mucin pool. There were intracellular mucin and signet ring cells present in the tumor. Tumor clles showed positive reaction to PAS, Alcin blue and some cytokeratin staining. Conclusion: Mucinous adenocarcinoma of the salivary glad is a rare malignant tumor, which mainly affects the palate and mouth floor of older patients. The tumor may originate from the acinic cell of mucous acinus or multi-potential cells of the salivary glands.