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The Chinese Journal of Dental Research

Year 2004
Volume 7 , Issue 2

Pages: 5 - 9

Relationships Between Risk Factors of Malignant Transformation of Oral Leukoplakia and the LSCP Classification and Staging System

Zheng Sun, DDS/Ning Li, PhD/Jie Huang, DDS

Objective: To explore the clinical significance of the LSCP classification and staging system through analysis of relationships between risk factors of malignant transformation of oral leukoplakia patients and the LSCP classification. Methods: Single factor chi-squared test was first carried to select the most significant factors with LSCP stages of oral leukoplakia (stage IV vs. I, II, and III) was examined by multiple logistic regression analysis. Results: Gender, site of lesions, clinical aspect and histopathological factors of lesions were chosen as risk factors incorporated into the multiple logistic regression model. The results showed that the risk of LSCP stage IV oral leukoplakia in female patients is higher than in male patients. The risk of lesions occurring in tongue and/or floor of mouth was higher than that in other site. The risk of verrucous leukoplakia was the highest among the clinical subtypes of lesions and the risk of severe dysplasia and moderate dysplasia classified as LSCP stage IV is higher than that of hyperplasia and mild dysplasia. Pathological features with moderate and severe dysplasia were the most important contributory factors to the LSCP classification. Conclusion: The LSCP classification and staging system is helpful in estimating the overall risk of malignant transformation of oral lesion, and is valuable in clinical follow-up and developing the best treatment plan.



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