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The Chinese Journal of Dental Research

Year 2004
Volume 7 , Issue 1

Pages: 41 - 44

The Study of Changes in the Temporomandibular Joint Under High Sustained Acceleration (+Gz) Condition Using an Animal Model

Zhenyu Sun, MS/Min Hu, DDS/Yin Yin, BDS/Jun Hou, DDS/Chuanbing Li, BDS, Dongxia Li, BDS

Objective: To establish an animal model to observe the effects of sustained high acceleration (+Gz) forces on temporomandibular joint (TMJ) and masticatory muscles. Methods: Forty-eight male Wistar rats were randomly divided into four groups of 12. Group A were normally fed and used as controls; group B were fixed with rat-kept devices for 5 mins; group C were exposed to +1Gz for 5 mins; and group D were repeatedly exposed to +10Gz (30s, onset rate about 0.5G/s, 5 times/day with +1Gz 1 min intervals, 3 weeks in total). One day after centrifuge treatment, animals were sacrificed. TMJs with surrounding tissues were observed under light and scanning electron microscopy. Results: No abnormal changes in animal behaviour and in the pathological characteristics were observed in groups A, B, and C. But in group D destruction of TMJ cartilage, articular disk and masticatory muscles were found. Conclusion: The animal model may be used to study the changes of repeated +Gz stresses on TMJ and masticatory muscles.



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