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The Chinese Journal of Dental Research

Year 2003
Volume 6 , Issue 4

Pages: 34 - 38

Experimental Study on Septic Arthritis of Temporomandibular Joint

Xieyi Cai/Chi Yang/Zhiyuan Zhang/Weiliu Qui/Qi Ha/Xudong Wang

Objective: To study the incidence, infectious route, and histopathological changes of infection in temporomandibular joint (TMJ), and to establish an animal model of TMJ infection hematogenously. Materials and Methods: Ninety-eight SD rats aged 30 days were divided into 3 groups: an experimental group, a blank control group, and a normal control group. The rats in the experimental group were injected with 0.5 mL suspension containing 6 X 108 cfu/mL S. aureus isolated from TMJ septic arthritis into tail veins, whereas the rats in the blank control group were injected with 0.5 mL saline. The rats in normal control group were not handled. The rats were sacrificed 1 day, 2 days, 4 days, 7 days, 2 weeks, 1 month, and 2 months postoperatively. The TMJs and blood were cultured, and histopathological examinations for TMJ were performed with light microscopy and electron microscopy. Results: The blood culture for microorganism was negative 24 hours after inoculation in all rats. S. aureus was found in TMJs 48 hours after inoculation. This course could continue for 2 weeks. TMJ septic arthritis occurred as early as 4 days after inoculation, although the incidence rate was low. TMJ infection mainly caused damage to chondrocyte and collagen. Conclusion: After inoculation, infection was seen in TMJs for several weeks. The incidence of TMJ septic arthritis was fairly low, but obvious damage to chondrocytes and collagen could be observed after TMJ infection.



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