Home Subscription Services

The Chinese Journal of Dental Research
About the Editor
Editorial Board
Author Guidelines
Submission Form
Reprints / Articles
Official Site

The Chinese Journal of Dental Research

Year 2003
Volume 6 , Issue 3

Pages: 38 - 43

Expression of Telomerase and Cyclin A in Ameloblastoma

Ming Zhong/Yangli Yue/Jie Wang

Objective: To study hTERT mRNA expression in ameloblastoma (AB) and its correlation with cyclin A, p53 protein and proliferation cell nuclear antigen (PCNA) and to investigate clinical biological significance. Methods: Expression of cyclin A and p53 protein in AB and expression of PCNA and hTERT mRNA was detected by Sp method and in-situ hybridization. Results: The positive ratios of hTERT mRNA, cyclin A , p53 protein and PCNA were 94.4% (51/54), 66.7% (40/60), 85.7% (42/49) and 78.1% (25/32), respectively. Strong correlations were found between hTERT mRNA and cyclin A, p53 protein and PCNA (rs = 0.914, 0.848, 0.804, P < 0.05). Conclusions: Telemerase activity has correlations with the accumulation of p53 protein and cell proliferation and differentiation. It is regulated by cyclin A and has a higher expression in phase S.



  © 2017 Quintessence Publishing Co Inc

Home | Subscription Services | Books | Journals | Multimedia | Events | Blog
Terms of Use | Privacy Policy | About Us | Contact Us | Advertising | Help | Sitemap | Catalog