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The Chinese Journal of Dental Research

Year 2003
Volume 6 , Issue 3

Pages: 26 - 31

Mucinous Adenocarcinoma of Salivary Glands

Yan Gao/Ping Di/Xin Peng/Guangyan Yu/Kaihua Sun

Objective: To investigate the clinicopathological features of mucinous adenocarcinoma of the salivary glands. Methods: The clinical manifestations and histopathological characteristics of 6 cases of mucinous adenocarcinoma of the salivary glands were studied by retrospective and routine histopathology and immunohistochemistry. Results: Mucinous adenocarcinoma often occurred in the palate (4 cases) and mouth floor (2 cases). The average age of patients was about 60 years (range 48-70) and males were affected more often than females (4:2). Pathologically, the tumor grew with the infiltration of surrounding tissues. The tumor consisted of unitary mucinous cells and a mucin pool was obvious. Cell pleomorphism and nuclear mitosis was often seen. Some tumors showed an acinus-like structure. Tumor cells often had an incomplete duct-like structure, with small clusters floating in the mucinous pool. There were intracellular mucin and signet ring cells in the tumor. Tumor cells showed a positive reaction to PAS, alcin blue and some cytokeratin staining. Conclusion: Mucinous adenocarcinoma of the salivary glands is a rare malignant tumor which mainly affects the palate and mouth floor of older patients. The tumor may originate from acinic cells of the mucous acinus or multi-potential cells of the salivary gland.



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