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The Chinese Journal of Dental Research

Year 2003
Volume 6 , Issue 2

Pages: 39 - 42

Cyclosporin A Down-regulates Expression of Intercellular Adhesion Molecule-1 in Human Oral Mucosal Fibroblasts

Yunzhi Feng, Tianyou Ling, Hangjiang Wu, Yunliang Li, Zhiwen Liu

Objective: To investigate the effects of cyclosporine A (CsA) on the level of intercellular adhesion molecule-1 (ICAM-1) expressed by oral fibroblasts (FB). Material and Methods: Fibroblasts were obtained from normal buccal mucosa (NM-FB) and cultured in vitro. The expression of ICAM-1 incubated with or without CsA in 10% fetal calf serum for 48 hours at 37C in 5% CO2 and air was monitored by cell-based enzyme-linked immunosorbent assay (ELISA). Results: The normal expression of ICAM-1 in oral mucosal fibroblasts is 0.324 0.030; CsA down-regulated the expression in a dose-dependent manner. Conclusion: CsA down-regulated the expression of ICAM-1 in oral mucosal FB, and may therefore be useful in the treatment of some oral mucosal disorders.



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