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The Chinese Journal of Dental Research

Year 2003
Volume 6 , Issue 1

Pages: 42 - 46

The Effect of Fluoride Overdose on the Proliferation and Apoptosis of Rat Incisor Ameloblasts

Hongchen Sun/Ming Liu/Jie Ouyang/Yabing Mu/Guangsheng Li

Objective: To observe the effect of fluoride overdose on the proliferation of the pure Wistar rats’ incisor ameloblasts. Material and Methods: Twenty healthy Wistar rats were randomly divided into 2 groups, Group I (the control) and Group II (receiving 50 mg/L F-). After 8 weeks’ treatment the AgNORs stain and TUNEL technique were used to analyze the effect of fluoride on the proliferation and apoptosis of ameloblasts. Results: Incremental lines in the incisors in Group II were clearly visible and eosinophilic granules had accumulated in the ameloblasts in the secretory stage. The number of AgNORs granules in the ameloblasts in the pre-secretory stage in Group II was lower than in Group I, and the difference was statistically relevant (p < 0.001); more ameloblasts experienced apoptosis or migrated in the secretory stage. Conclusion: Fluoride overdose can inhibit proliferation of the ameloblasts and accelerate their apoptosis, which is what is meant by fluorosis.



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