Objective: To analyze the mechanism of microcirculation disorder in the glossodynia and find a new, effective treatment. Methods: Eighteen cases of microcirculation disorder in the tongue were studied by histopathology, hemorheology and nail microcirculation, and treated by intravenous injection of angelica to promote blood circulation and prevent stasis. Results: Hyperviscosity of blood was found in this group of patients. Abnormal microvessels were observed by microcirculation examination, though vasculitis was not detected in the tongue tissue. Conclusion: Microcirculation disorder may be an important cause of glossodynia. In elderly patients, cardiovascular and mental disease should be considered. Starting with the theory of blood stasis from Chinese medicine, this study shows that a treatment combining Chinese and Western medicine can help such patients: The injection of angelica can improve microcirculation.