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The Chinese Journal of Dental Research

Year 2001
Volume 4 , Issue 4

Pages: 64 - 74

Effect of Topical Administration of a Biphosphonate (Zoledronate) on Orthodontic Tooth Movement and Periodontal Tissue in Rats

Chang Liu/Zhe Wu/Yuan Ping Chen/Xin Hua Sun/Hai Dong Wei

Objective: To study the effects of topical administration of zoledronate solution on the distance of tooth movement, morphologic change of periodontal tissue, and cells undergoing apoptosis. Methods: Forty-two rats were divided into two groups. Zoledronate solution was injected under the palatal submucosal area adjacent to the left maxillary first molar in the experimental group 3 days prior to the use of the orthodontic appliance. The control group was treated with an injection of 0.9% NaCl solution in the corresponding area at the same time. Local administration was performed every 3 days, for a total of 9 administrations. Mesial force was applied for 0, 3, 7, 14, and 21 days. The measurement of tooth movement was performed with a stone cast of the maxillary jaw, made by taking an impression with precise material before the application of force and after the rats were sacrificed. After the rats were sacrificed, the tissue was fixed by perfusion of the heart with 4% paraformaldehyde in 0.1 mol/L phosphate buffer. Sections were stained with hematoxylin and eosin and the TUNEL method, then observed with a light microscope. Results: The distance of tooth movement, except at 0 and 3 days, in the experimental group was significantly smaller than in the control group. The number of osteoclasts on the pressure side in the experimental group was significantly smaller than that in the control group. On the side receiving pressure, the number of odontoclasts on the surface of the distal root above the interradicular septum showed no statistical difference between the two groups at any timepoint other than day 14. There were apoptotic osteoclasts and odontoclasts in both groups, and the number of apoptotic osteoclasts and odontoclasts in the experimental group was markedly larger than that in the control group at every time point. Conclusion: Zoledronate may be a useful agent to reinforce the anchorage of the tooth undergoing orthodontic pressure; it can affect osteoclasts and odontoclasts specifically and reduce the extent of resorption of alveolar bone and cementum. This result may be attributable to the apoptosis induced by the cytotoxic effect of zoledronate on osteoclasts and odontoclasts.



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