Home Subscription Services
 
   

 
The Chinese Journal of Dental Research
About the Editor
Editorial Board
Author Guidelines
Submission Form
Reprints / Articles
Permissions
Advertising
MEDLINE Search
Official Site
 
 
 
 
 
FacebookTwitter

Publication:
The Chinese Journal of Dental Research

Year 2001
Volume 4 , Issue 4

Back
Pages: 56 - 59

Stereologic Analysis in Oral Precancerous Lesions and Squamous Cell Carcinoma

Shan Gao/Shufan Liu/Chunsheng Zhang/Zihua Shen/Longxiang Peng

Objective: To analyze the spinous cells of the oral epithelium by stereologic method, and to determine the malignant process in the quantitative change of the nucleus. Methods: Forty-eight specimens were taken from the oral mucosa. These were comprised of normal mucosa, oral submucous fibrosis, leukoplakia, epithelial dysplasia, and squamous cell carcinoma. The measurements were made by an interactive image analysis system (IBAS-II, OPTON). The stereologic parameters were calculated. Results: Nuclear volume density and surface density increased steadily from normal mucosa, through lesions, to carcinoma (P < .01); cytoplasmic volume density, cell mean volume, and mean diameter decreased progressively (P < .01 or P < .05). Four parameters showed significant differences when the group of carcinoma was compared with the other four groups (P < .01 or P < .05). Conclusion: Stereologic parameters could objectively reveal the biologic and morphologic features during malignant development, explain the malignant process from the quantitative change of nuclei from normal mucosa, through lesions, to carcinoma, and distinguish carcinoma from other lesions.

 

 

  © 2014 Quintessence Publishing Co Inc
 

Home | Subscription Services | Books | Journals | Multimedia | Events | Blog
Terms of Use | Privacy Policy | About Us | Contact Us | Advertising | Help | Sitemap | Catalog