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The Chinese Journal of Dental Research

Year 2001
Volume 4 , Issue 3

Pages: 37 - 43

Chemopreventive Effect of N-4-(Hydroxycarbophenyl) Retinamide on Oral Precancerous Lesions in Hamsters and Humans

Zheng Sun, DDS, MS/Ning Li, PhD/Xiaoyong Liu, DDS/Jianbin Wang, DDS, PhD/Rui Han, PhD

Objective: To study the chemopreventive effect of N-4-(Hydroxycarbophenyl) Retinamide (Rpi), a retinoid analogue, on oral precancerous lesions in hamsters and humans. Methods: In the animal experiment, the animals with oral precancerous lesions induced by DMBA were divided into 4 groups: oral ingestion treatment, oral plus topical treatment, topical treatment, and the control. At the end of the experiment, the cheek pouches with lesions were excised, the number of tumors in each oral cavity was counted, the tumor volume was calculated, and several lesion sections were cut at 5 Ám for histopathologic examination, AgNOR, and PCNA analysis. In the human intervention trial, selected patients with oral leukoplakia were divided into an Rpi-treated group and a placebo group. The lesions were determined by the numbers and dimensions before and at the end of treatment. Results: In the animal experiment, the mean tumor burden in the oral ingestion group, the oral plus topical treatment group, and the topical treatment group was reduced by 52.1%, 75.3%, and 57.3%, respectively (P < .01). The number of AgNOR and the labeling index of PCNA were also significantly reduced. In the human intervention study, after a 9-month treatment, 35.4% of the patients in the Rpi-treated group showed complete remission and 47.6% showed partial remission, while only 11.5% of the patients in the placebo group showed a partial remission. Conclusion: These results indicate that Rpi has a significant therapeutic effect on oral precancerous lesions and that Rpi is a promising candidate in the chemoprevention of oral cancer.



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