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Publication:
The Chinese Journal of Dental Research

Year 2001
Volume 4 , Issue 2

Back
Pages: 56 - 58

Interleukin-1 Induction on Nerve Growth Factor Expression in Human Dental Pulp Cells

Hanguo Wang, MS/Minzhen Xiao, DDS/Jun Liu, PhD

Objective: To investigate the biology of the increase of nerve growth factor expression in human dental pulp cells during pulp inflammation. Methods: Immunohistochemistry was separately conducted for nerve growth factor at 6 hours, 12 hours, 24 hours, 48 hours, and 72 hours following 30 g/mL interleukin-1 (IL-1) action on human dental pulp cells. Results: Nerve growth factor expression increased significantly at 12 hours, 24 hours, and 48 hours after IL-1 addition. Conclusion: Inflammatory factor IL-1 induces nerve growth factor expression in human dental pulp cells at the molecular level and is involved in the dental pulp inflammatory process.

 

 

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