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The Chinese Journal of Dental Research

Year 2001
Volume 4 , Issue 1

Pages: 44 - 46

Determination of Calcitonin Gene-Related Peptide in the Blood of Patients with Trigeminal Neuralgia

Shi Hui Hu, DDS/Xiao Zhong Jiang, DDS/Yun Fu Zhao, DDS/Yuan Liu, DDS/Chao You Song, MD

Objective: To determine whether calcitonin gene-related peptide participates in the attacks of trigeminal neuralgia and to get a deeper understanding about its pathogenic mechanism. Methods: Seven patients were studied. During the attacks, venous blood was sampled from both the external jugular vein and the cubital fossa vein ipsilateral to the pain; after operations the venous blood from the external jugular vein was sampled again. Plasma levels of calcitonin gene-related peptide were determined using sensitive radioimmunoassays. Results: During the attacks of trigeminal neuralgia, the levels of calcitonin gene-related peptide in the external jugular vein blood were significantly higher than that in cubital fossa vein blood and postoperative external jugular vein blood. Conclusion: Excessive synthesis and release of calcitonin gene-related peptide in the trigeminal nerve may promote the release of substance P, cause the intense paroxysmal pain, and form a local neurogenic inflammation.



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