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The Chinese Journal of Dental Research

Year 2001
Volume 4 , Issue 1

Pages: 36 - 39

Effects of Autogenous Periodontal Ligament Cell Transplantation on Periodontal Tissue Regeneration in Dogs

Long Ou, DDS/Hongwei Liu, DDS PhD/Min Hu, DDS, PhD/Jinfan Pang, DDS/Zhiping Yuan, DDS/Liang MA, DDS

Objective: To evaluate the effect of autogenous periodontal ligament cell (PDL) transplantation in periodontal tissue regeneration. Methods: PDL cells from the same dog were cultured with a-Mem. One x 105 cells of the first passage were allowed to attach to the collagen membrane for 24 hours. The membrane-cells were transplanted into a periodontal defect in the same dog. The defects were then covered with e-PTFE membranes. Defects covered with e-PTFE only; without membrane-cells, served as controls. Eighteen teeth from 6 dogs in each group were included in the study: The dogs were sacrificed at 6 weeks. Results: The results showed that new bone formation (4.00 013 mm) in the test group was significantly higher than that in the control group (3.09 0.28 mm, P<0.05). The new cementum formation in the test group was better than in the control group (P<0.05). Conclusion: The results suggest that PDL cell transplantation with the guided tissue regeneration technique could enhance periodontal tissue regeneration in dogs.



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