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The Chinese Journal of Dental Research

Year 2001
Volume 4 , Issue 1

Pages: 31 - 35

An Experimental Study of the Effects of Natural Carotene on DMBA-Induced Oral Buccal Mucosa Premalignant Epithelia in Golden Hamsters

Yangzhi Xu, DDS, Shenglin Li, DDS/Kuihua Zhang, DDS, Xiaoling Wang, MD/Shaocheng Li, MD/Zibin Gao, DDS/Yu Geng, DDS/Fu Lin Chen, DDS, PhD/Tian Qui Mao, DDS/Xiao Ming Gu, DDS, PhD

Objective: To study the effect of natural carotene on dimethylbenzanthracent (DMBA) induced oral premalignant epithelia in Syrian golden hamsters. Methods: The hamsters were divided into a control group, oral premalignant epethelia group, carotene administration group (applied into stomach with 0.5% natural carotene, 15 mg/kg/day; 5 days a week for 4 weeks), and topical application group (applying natural carotene paste 10 mg/1x1cm2, 5 days a week for 4 weeks. The animals were sacrificed at the end of the experiment and buccal mucosa from the left and right sides were excised for histopatholigic examination. Results: Both gastric and topical application groups had evident effects, but the effect of the former group was superior in treating oral premalignant epithelia than that of the latter group. Conclusion: Natural carotene could effectively reverse dimethylbenzanthracene-induced oral premalignant epithelia in hamsters toward normal.



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