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The Chinese Journal of Dental Research

Year 2000
Volume 3 , Issue 4

Pages: 49 - 53

Effect of Nifedipine on Proliferation and DNA Synthesis of Human Gingival Fibroblasts

Weibin Sun, DDS/Chunmei Jiang, DDS/Shizhong Zheng, MS

Objective: To investigate the effect of Nifedipine, a calcium channel blocker, on cellular proliferation in gingival fibroblasts in vitro. Methods: Gingival fibroblasts were cultured and incubated with various concentrations of Nifedipine (23.5, 108, 360, and 1200 ng/mL) for up to 7 days. Results: Cell numbers were significantly different among these groups on the sixth and seventh days, especially between the 1200 ng/mL or 360 ng/mL and the other concentrations. Conclusion: Nifedipine can influence proliferation of gingival fibroblasts in high concentrations.



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