Home Subscription Services
 
   

 
The Chinese Journal of Dental Research
About the Editor
Editorial Board
Author Guidelines
Submission Form
Reprints / Articles
Permissions
Advertising
MEDLINE Search
Official Site
 
 
 
 
 
FacebookTwitterYouTube

Publication:
The Chinese Journal of Dental Research

Year 2000
Volume 3 , Issue 2

Back
Pages: 58 - 60

Abnormalities of the Human Rb Tumor Suppressor Gene in Oral Squamous Cell Carcinoma

Hongzhang Huang, DDS, MSc/Jianguang Wang, DDS, PhD/Jinrong Li, DDS

Objective: To investigate the status of Retinoblatoma (Rb) gene in 30 patients with primary oral squamous cell carcinoma (OSCC) and 3 healthy control samples. Material and methods: We determined the status of Rb tumor suppressor gene in oral squamous cell carcinoma using a DNA southern blotting assay with Digoxin (Dig) labeled Rb cDNA probe. Results: The structural abnormalities of Rb tumor suppressor gene were detected in 8 of the 30 invasive OSCC samples analyzed (7/30). 7 cases contained partial gene deletion, and there was 1 case of gene rearrangement. The structural abnormality rate of Rb is 26.7%. No correlation was found between the alteration of Rb gene with the sex, age, site of primary tumor, level of histopathological differentiation, and TNM staging. Conclusions: Our study shows that abnormalities of the Rb tumor suppressor gene occur in oral squamous cell carcinoma, which include Rb deletion and Rb rearrangement, but its abnormality rate is low.

 

 

  © 2014 Quintessence Publishing Co Inc
 

Home | Subscription Services | Books | Journals | Multimedia | Events | Blog
Terms of Use | Privacy Policy | About Us | Contact Us | Advertising | Help | Sitemap | Catalog