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The Chinese Journal of Dental Research

Year 2000
Volume 3 , Issue 2

Pages: 58 - 60

Abnormalities of the Human Rb Tumor Suppressor Gene in Oral Squamous Cell Carcinoma

Hongzhang Huang, DDS, MSc/Jianguang Wang, DDS, PhD/Jinrong Li, DDS

Objective: To investigate the status of Retinoblatoma (Rb) gene in 30 patients with primary oral squamous cell carcinoma (OSCC) and 3 healthy control samples. Material and methods: We determined the status of Rb tumor suppressor gene in oral squamous cell carcinoma using a DNA southern blotting assay with Digoxin (Dig) labeled Rb cDNA probe. Results: The structural abnormalities of Rb tumor suppressor gene were detected in 8 of the 30 invasive OSCC samples analyzed (7/30). 7 cases contained partial gene deletion, and there was 1 case of gene rearrangement. The structural abnormality rate of Rb is 26.7%. No correlation was found between the alteration of Rb gene with the sex, age, site of primary tumor, level of histopathological differentiation, and TNM staging. Conclusions: Our study shows that abnormalities of the Rb tumor suppressor gene occur in oral squamous cell carcinoma, which include Rb deletion and Rb rearrangement, but its abnormality rate is low.



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