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Publication:
Chinese Journal of Dental Research

Year 2000
Volume 3 , Issue 1

Back
Pages: 63 - 66

Detection of Interleukin-8 in Exudates from Normal and Inflamed Human Dental Pulp Tissues

Ximin Guo, DDS, PhD/Zhongying Niu, DDS/Mingzhen Xiao, DDS/Ling Yue, DDS/Huaixiu Lu, BS

Objective: The purpose of this study was to investigate the level of IL-8 in exudates clinically obtained from normal and inflamed human dental pulp tissues so as to reveal the possible relationship between IL-8 and pulpitis. Methods: Samples of 2 Ál of pulpal exudate from each normal or clinically diagnosed as acute or chronic pulpitis teeth was obtained by filter paper strips and IL-8 level was measured by ELISA method. Results: No IL-8 was detected in the samples from normal pulp, but significant amount of IL-8 appeared in inflamed pulp tissues, and the level of IL-8 in exudates of acute stage of pulpitis was higher than that of chronic stage (P < 0.01). Conclusions: This study demonstrates that IL-8 is produced and accumulated in pulp inflammation and may play a role in the occurrence and development of human pulpitis.

 

 

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