Objective: To investigate the distribution and change of transforming growth factor beta 1 (TGF-ß1) in rat periodontal tissue and understand the role of TGF-ß1 in orthodontic tooth movement.
Methods: Force was applied on right maxillary first molars in rats, followed by the examination of the decalcified alveolodental connected tissue in different stages of tooth movement. An immunohistochemical staining technique (SP method) was used for this examination.
Results: TGF-ß1 exists in normal periodontal tissue. The expression of it in periodontium increases during orthodontic tooth movement. From 5 to 10 days after applying force, the expression at the tension site was significantly greater than that at the pressure site.
Conclusions: Changes in TGF-ß1 levels play an important role in the remodeling of periodontal tissue during orthodontic tooth movement, and can powerfully promote bone formation.