Objective: To study the possibility of neuroendocrine feature of salivary adenoid cystic carcinoma (SACC). Methods: Immunohistochemical staining was operated in SACC with S-100 protein, neurospecific enolase (NSE), chromogranin A, and synaptophysin, which are specific and correlative with neuroendocrine cells and neoplasias. Results: The positive expression of S-100, NSE, chromogranin, and synaptophysin were 42, 32, 8, and 7, respectively, in 50 cases of SACC. Conclusion: Neuroendocrine feature in some SACC cells is possibly indicated. (CJDR 1999;2(3):65-67)