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Chinese Journal of Dental Research

Year 1999
Volume 2 , Issue 3

Pages: 21 - 24

Induction of Reparative Dentin Formation in Dogs with Combined Recombinant Human Bone Morphogenetic Protein 2 and Fibrin Sealant

Wen Hong Ren, MS/Lian Jia Yang, DDS/Shao Zhong Dong, PhD

Objective: To investigate the reparative dentin formation induced by the complex of recombinant human bone morphogenetic protein 2 (rhBMP2) and fibrin sealant (FS) in dogs. Methods: Freshly exposed pulp of molars, premolars, and canines were treated, respectively, with the complex of rhBMP2-FS, rhBMP2, and Ca(OH)2 paste, which served as control. Result: Wound healing of exposed pulp treated with the complex of rhBMP2 and FS seemed better than that with rhBMP2 alone. Dentin bridge formation was observed at 1 week when pulp was treated with the complex and at 4 weeks with rhBMP2 and Ca(OH)2. At 9 weeks after operation, more amount of tubular dentin bridge formation was found in pulp treated with the complex than with rhBMP2. Conclusions: The results suggest that synergistic effects of fibrin and rhBMP2 existed and that rh-BMP2 with FS carrier can be used as bioactive pulp capping agent. Together, these agents can induce a large amount of dentin and enhance healing of exposed pulp. (CJDR 1999;2(3)21-24).



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