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Publication:
Chinese Journal of Dental Research

Year 1999
Volume 2 , Issue 2

Back
Pages: 54 - 57

Mechanical Stress Regulation and Proliferation of Rat Mandibular Condylar Chondrocytes in Vitro

Hongmei Yang, DDS, PhD/Songjiao Luo, DDS

Objective: To study the proliferative changes of cultured rat mandibular condylar chondrocytes effected by mechanical stress. Method: Flow cytometry (FCM) was used to explore the changes of cellular DNA content and cell cycles of passaged condylar chondrocytes. Results: FCM results indicated that proliferation of cultured rat mandibular condylar chondrocytes decreased with stress duration, with marked differences between the experimental and control groups. Conclusion: Within given force duration and force range (0-207g/an2), proliferation of rat mandibular condylar chondrocytes increased with force magnitude, reaching the maximum 6 hours after application of stress. Cellular proliferation decreased when the chondrocytes were cultured under continuous stress for 24 hours. The mechanism for these proliferative changes requires further study.

 

 

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