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Publication:
Chinese Journal of Dental Research

Year 1999
Volume 2 , Issue 1

Back
Pages: 16 - 20

Selection of Quantitative Criteria for Evaluating Metastases of a Highly Metastatic Salivary Adenoid Cystic Carcinoma Cell Line to the Lungs of Nude Mice

Gu/Qiu/He/Zhang/Zhou

Objective: To select reliable quantitative criteria for evaluating metastases of a highly metastatic salivary adenoid cystic carcinoma cell line (ACC-M) cell to the lungs of nude mice. Materials and Methods: The within-group coefficients of correlation of 5 parameters were measured from lung slides using a video image digital analysis system (VIDAS), and the intergroup coefficients of correlation of 6 sets of parameters from all the lungs, which were taken from ACC-M lung metastases models, were calculated and statistically analyzed. Results: The within-group coefficients of correlation of 5 parameters are as follows: ratio of area of metastases, t = 0.9 (P < 0.001); area of metastases, t = 0.7 (P < 0.05), size of lung section, numbers of metastases, and size of the largest metastic focus all t < 0.4 (P > 0.05). The intergroup coefficients of correlation of the parameters are as follows: ratio of area of metastases was assigned 1, weight of the lung was 0.9755, and area of metastases was 0.8628. Conclusion: For evaluating lung metstases of ACC-M, the ratio of area of metastases and weight of the lung are precise; the area of metastases is also signficiant within the 6 quantitative parameters.

 

 

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