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The Chinese Journal of Dental Research

Edited by Xu Chen MA

Official journal of the Chinese Stomatological Association

ISSN (print) 1462-6446 • ISSN (online) 1867-5646


Fall 2010
Volume 13 , Issue 2

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Saponins from Plumeria acuminata Ait Induce Cell Growth Inhibition and Apoptosis of Oral Squamous Carcinoma Cells

Susanto, Hendri / Fakhrudin, Nanang / Murti, Yosi Bayu / Supriatno / Siswomiharjo, Widowati

Pages: 153 - 156

Objective: To investigate the cytotoxic and apoptotic effects of saponins from Plumeria acuminata Ait on oral squamous carcinoma cells (OSCC). Methods: OSCC cells seeded at 2 104 cells/well in a 96-well plate were treated with saponins from P. acuminata Ait and cisplatin in various concentrations for 24 h. Trypan blue dye exclusion assay and ethidium bromide/acridine orange were used to evaluate their cytotoxic and apoptotic effects on the cells, respectively. Results: The results showed that both saponins and cisplatin had cytotoxic and apoptotic effects on OSCC cells. Conclusion: Saponins from P. acuminata Ait may be potential anti-cancer agents for OSCC.

Keywords: apoptosis, OSCC, Plumeria acuminata Ait, saponins

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