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Quintessence Publishing: Journals: CJDR

 

The Chinese Journal of Dental Research

Edited by Xu Chen MA

Official journal of the Chinese Stomatological Association

ISSN (print) 1462-6446 • ISSN (online) 1867-5646

Publication:

Summer 2012
Volume 15 , Issue 1

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Lipoprotein-associated Phospholipase A2 and Serum Lipid Levels in Supjects with Chronic Periodontitis and Hyperlipidemia

Zhou, Shuang Ying / Xiao, Wen Mei / Ouyang, Xiang Ying

Pages: 25 - 29
PMID: 22866279

Objective: To evaluate the relationships between clinical periodontal parameters and levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and lipid profile markers in subjects with or without hyperlipidaemia.
Methods: Forty chronic periodontitis (CP) subjects with hyperlipidaemia (CP/HPL group), 40 systemically healthy CP subjects (CP group) and 20 systemically and periodontally healthy subjects (control group) were enrolled. The clinical periodontal parameters, the serum concentrations of Lp-PLA2, lipid profiles including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c) and white blood cell (WBC) counts were determined and compared between different groups. Linear regression analysis was performed to identify the contributing factors of Lp-PLA2.
Results: Serum Lp-PLA2 level in the CP/HPL group and the CP group was significantly higher than in the healthy group. TC and TG levels in the CP/HPL group were higher than in the CP and control groups. No difference was observed for levels HDL-c and LDL-c and WBC counts among the groups. Linear regression analysis showed that the serum level of Lp-PLA2 was positively associated with bleeding on probing and WBC counts.
Conclusion: Elevated level of Lp-PLA2 is associated with periodontal inflammation, indicating that periodontal treatment could reduce the risk of cardiovascular disease in CP subjects with hyperlipidaemia.

Keywords: periodontitis, hyperlipidaemia, lipoprotein-associated phospholipase A2

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