Treatment-planning patients with dentofacial deformities begins with the desired final occlusal results in mind. Examination of occlusal models and subsequent feasibility model surgery determine whether segmentalization of one or both arches is necessary to accomplish the final occlusal scheme desired. Segmentalization of the maxilla and/or mandible may be used to resolve transverse or arch configuration discrepancies, level occlusal plane(s), correct dentoalveolar inclination, and/or remove extraction spaces by osteotomy. With so many variables to consider, it is often difficult even for an experienced clinician to systematically evaluate and select the ideal location of interdental osteotomies prior to presurgical orthodontics. This manuscript describes an algorithmic approach to diagnosis and treatment planning that will assist the clinician in determining the most favorable location(s) for interdental osteotomy(ies).