This case report describes the treatment of a 14-year-old female patient with maxillary bilateral lateral incisor agenesis. all-ceramic resin-bonded fixed partial dentures (CRBFPDs) were selected as the most conservative and esthetic treatment option. Single-retainer cantilever zirconia-based CRBFPDs were fabricated and adhesively bonded to the abutment teeth, closely following the protocols suggested by the most recent scientific evidence. Proper case selection, preparation technique, and bonding protocols are fundamental for long-term clinical success. in appropriate cases, zirconia-based CRBFPDs provide a time- and cost-effective treatment option for missing lateral incisors. Further clinical trials are necessary to confirm the promising results of these restorations. (Am J Esthet Dent;2:226–237.)