Salivary Biomarkers for Oral and Systemic Diseases
David T. Wong, DMDFriday, February 7
10:45 am - 11:30 am
Saliva has long been considered a “mirror of the body” that reflects the state of overall health. A wide range of systemic diseases, such as diabetes and Sjögren syndrome, have oral manifestations that clinicians (physicians and dentists) encounter in patients at various stages of disease development. Advances in the science of salivary diagnostics have led to identification of disease signatures of candidate biomarkers and/or confirmation of genetic susceptibility for systemic conditions, particularly in molecular oncology. Development of the salivary proteome, transcriptome, micro-RNA, metabolome, and microbiome as diagnostic alphabets fully enables saliva to be translated for personalized individual medicine applications. Salivary biomarker panels have been developed for oral cancer, lung cancer, pancreatic cancer, breast cancer, and ovarian cancer. Coupled with the development of point-of-care technologies and the emerging trend of chairside screening for medical conditions, the clinical impact of scientifically credentialed salivary biomarkers for molecular oncology application will improve access to care, reducing health disparities and impacting global health.