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The Role of Inflammation in Oral-Systemic Interactions


Thomas E. Van Dyke
Friday, February 7
1:15 pm - 2:00 pm

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Recent studies have suggested a relationship between oral infection, in particular periodontal disease, and systemic diseases that goes beyond simple associations. Epidemiologic studies have implicated periodontal disease as imparting excess risk for the development of cardiovascular disease and stroke and as a risk factor for preterm low–birth weight babies in pregnant women. In addition, studies in diabetics have revealed that untreated periodontal disease can lead to diabetic complications and have a direct impact on glycemic control in diabetic patients. The available evidence associating periodontal disease with risk for systemic disease centers on the role of bacteria from the oral cavity and bacteremia but always in the context of initiation or amplification of local and systemic inflammation. The role of inflammation in cardiovascular disease, pregnancy complications, obesity, and diabetes, particularly type 2, is well documented. The role of periodontal inflammation as a local, extravascular source of inflammation that has significant impact on systemic inflammation and inflammatory disease is beginning to be understood. This presentation will provide an overview of current concepts in local infection and inflammation as modifiers of systemic disease.


Thomas E. Van Dyke, DDS, PhD,