Three prerequisites must be met in order for growth factor/matrix combinations to be effective in the clinic: First, the growth factor must bind to the matrix/ carrier and be delivered to the site in a form that can be active. Second, the growth factor must be at the site long enough to affect the cells responsible for tissue formation. Third, the growth factor must alter cellular activity. Certain growth factor/matrix carrier combinations have data that support all of these prerequisites, while others do not. This presentation will review the evidence for these prerequisites with regard to specific growth factor/matrix carrier combinations. The most clinically effective growth factor/matrix carriers are likely to have data to support each of them.
David L. Cochran, DDS, MS, PhD, MMSC, is a graduate of the University of Virginia and received his DDS and PhD in biochemistry from the Medical College of Virginia. He also was trained in periodontology at the Harvard School of Dental Medicine. He was recently awarded an honorary doctorate from the University of Bern in Switzerland for his contributions to implant dentistry. He currently serves as professor and chairman of the Department of Periodontics at the University of Texas Health Science Center at San Antonio’s Dental School. He is also currently president of the Academy of Osseointegration and has served in all officer positions with the American Academy of Periodontology, including president. Dr Cochran is a Diplomate of the American Board of Periodontology and has published numerous scientific articles and abstracts on various periodontal biochemistry and implant topics.
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