One of the many major advances made in the past decade in the field of bioengineering of oral, dental, and craniofacial tissues is the clinical implementation of biologic growth factors for periodontal and alveolar ridge reconstructions. In addition, next-generation biologics and advanced biomaterials can greatly improve space maintenance, reduce surgical operatory time, and potentially provide more predictable clinical outcomes. This presentation will highlight new developments in novel biologics, scaffolding matrices, and rapid prototyping approaches for tooth and dental implant reconstructions, with particular emphasis on clinical application. At the same time, the clinical feasibility of using cell and gene therapy approaches—many of which are also entering the clinical arena— will be described. (This research has been funded by the National Institutes of Health NIH/NIDCR DE 13397.)
William V. Giannobile, DDS, DMSC, is the Najjar Endowed Professor of Dentistry and Biomedical Engineering and the director of the Michigan Center for Oral Health Research at the University of Michigan School of Dentistry. Dr Giannobile previously served as a faculty member at Harvard and the Forsyth Institute in Boston. In 2006, he completed his sabbatical as a visiting professor at the Biotechnology Institute of Regenerative Medicine at the University of Genova Medical School in Italy. Dr Giannobile has lectured extensively in the area of periodontal regenerative medicine and tissue engineering. He currently serves as the editor-in-chief of the Journal of Dental Research as well as a consultant on dental devices to the FDA. Dr Giannobile is the recipient of the 2011 Distinguished Scientist Award from the American Academy of Periodontology for his research contributions to the field.
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