Successful osseointegration is predicated on the placement of dental implants into a sufficient volume of bone. When teeth are lost due to trauma or periodontal disease, there is often a lack of adequate bone volume. A number of different techniques have been developed to reconstruct deficient alveolar ridges to allow dental implant placement in either a simultaneous or staged approach. Advances in tissue engineering may offer solutions that resolve bone volume deficits and soft tissue defects while at the same time eliminating some of the concerns posed by current techniques (eg, patient morbidity and predictability of results). Recombinant human platelet-derived growth factor (rh-PDGF-BB) has been extensively used as a potent regenerating factor in orthopedics and periodontics with success. The principal aim in hard tissue regeneration is to eliminate the need for autogenous bone harvesting and possibly eliminate the nonresorbable membrane. We are moving toward an era where less invasive treatment regimes are available to minimize complications and side effects of surgical procedures, increase success rates, and decrease patient morbidity and technical difficulties. The maturation of tissue engineering and its application to clinical surgical procedures has helped create a new paradigm.
Isabella Rocchietta, DDS, is currently a research consultant for the Institute for Dental Research and Education. She received her dental degree in 2002 with full marks from the University of Milan, Italy. She was then awarded a one-year scholarship from the Department of Medicine at the University of Milan. She is an active member of the Experts Council of the Osteology Foundation, the Academy of Osseointegration, and the Italian Society of Periodontology. She is also a member of the European Academy of Osseointegration and chairman of its Junior Committee. Dr Rocchietta has authored several national and international peer-reviewed publications as well as book chapters for various multiauthor texts.
Platform: PC and Mac DVD-ROM