Repair of periodontal soft and hard tissue defects caused by periodontal disease or trauma is a major goal of reconstructive therapy. The field of regenerative medicine combines advances in materials science and the life sciences to repair tissues and organs. Over the past decade, investigators have begun to utilize signaling molecules such as growth factors and biomimetic peptides to restore tooth support lost due to damage to the alveolar process. This presentation will review emerging therapies in the areas of materials science, growth factor biology, and cell and gene therapy. In addition, the presentation will highlight the use of polymeric delivery systems and image-based scaffolding technologies that aid in the targeting of proteins, genes, and cells to oral and periodontal lesions for reconstruction of periodontal and peri-implant defects. The presentation will conclude with a discussion of the combined approach of regenerative molecule delivery and host modulation therapies to treat periodontal osseous defects.
William V. Giannobile, DDS, DMSc, is the Najjar Endowed Professor of Dentistry and Biomedical Engineering and the director of the Michigan Center for Oral Health Research at the University of Michigan School of Dentistry. He is a diplomate of the American Board of Periodontology as well as a consultant to both the United States Food and Drug Administration and the National Institutes of Health. In addition to publishing more than 125 articles, textbook chapters, and abstracts and lecturing extensively in the area of periodontal regenerative medicine and tissue engineering, Dr Giannobile serves as an associate editor for the Journal of Periodontology and on the editorial boards of several journals. He maintains a private practice limited to periodontics and implant dentistry in Farmington Hills, Michigan
Approximate Running Time: 60 minutes