The goal of clinical investigation in oral and maxillofacial regeneration is to determine the safety and efficacy of new biologics for the benefit of patients, which requires that researchers select appropriate animal models and corresponding experimental designs to enable the next steps toward human investigation. This book guides researchers in creating protocols that lead to meaningful outcomes. Written by a distinguished coterie of contributors with experience in preclinical trials, chapters outline how to create workable protocols, gain maximum information from preclinical investigations, and avoid common early career errors. Covered topics include research in soft and hard tissue, osseointegrated implants, periodontal regeneration, ridge preservation, horizontal and vertical ridge expansion, and augmentation of the sinus floor. Biomaterials used for regenerative efforts include osteoconductive products as well as tissue engineering. This text is an essential reference for researchers in every discipline of dentistry.
256 pp; 260 illus (mostly color) ISBN: 978-1-85097-211-2, 9781850972112